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Safe T21 express™ Prenatal Screening is a high-sensitivity fetal chromosomal disease detection technology that analyzes the DNA released by the fetus in the maternal blood circulation during pregnancy.

This technology is mainly aimed at early detection of common chromosomal disorders in the fetus and is more accurate than traditional Down's screening (ultrasound examination, serum screening method).









Advanced Version

Standard Version

Chromosomal trisomy

22

3

Microdeletion syndrome

126

7

Sex chromosome related diseases

4

4

Test code

SAFE21P

SAFE21

Sample requirements

10mL blood tube x 1

10mL blood tube x 1

Test time (working days)

5 *

5 *

Test fee

Original: $9900

Special Offer: $7600

Original: $8800

Special Offer: $5500


Inquiry & Booking: 3585 8533

Y-Chromosome DNA Test

In the 1970’s scientists discovered that fetal DNA passes through the placenta and enters the maternal blood circulatory system in the form of fetal metabolites or fetal DNA fragments. Experts point out that, the longer the fetus stays in the womb, the more concentrated the fetal DNA fragments will be in the maternal blood. In addition, the faster the diffusion process, the more fetal DNA fragments will be found in the maternal blood.
To summarize, a longer gestation period and faster diffusion process, results in more fetal DNA fragments in the maternal circulatory system. Nowadays, fetal sex can be determined through the application of advanced maternal blood DNA testing technology as early as 5 gestation weeks. The test involves isolating the fetal DNA fragments from the maternal serum, and then extracting and amplifying them. Once millions or possibly billions of copies have been made, the male DNA will be tested with the Sex-determining Region Y (SRY) markers.
In males, Y DNA is the genetic material that is inherited from the father only, which is crucial material for the fetus to develop as a male. Since Y DNA is inherited from the father and then passed on to the son, it can be used in paternity confirmation by simple comparison.

Test Details

Code Test Sample format TAT (working day)
Yi Yi Y-chromosome maternal serum test 10mL CELL-Free BCT x 1 1 Enquiry
YCHR5 Y-chromosome maternal serum test (5 weeks) 10mL CELL-Free BCT x 1 1 Enquiry
YCHR6 Y-chromosome maternal serum test (6 weeks) 6mL CELL-Free BCT x 1 1 Enquiry
YCHR Y-chromosome maternal serum test (7 weeks +) 6mL CELL-Free BCT x 1 1 Enquiry

Test Features

1. No Fasting is required

2. Non-invasive, inflicting minimal harm to the fetus

3. High sensitivity, a tiny amount of fetal Y-DNA can be detected precisely

4. High accuracy, >99.995%

Paternity Testing

Parentage tests are used to determine whether two individuals have a biological parent-child relationship. It is done by collecting and analyzing DNA from the alleged parent and child. The child’s profile is compared with the profile of the mother and alleged father to confirm that he or she has inherited DNA from the alleged father. Statistical analysis is then performed to calculate the Paternity Index, which determines the probability of paternity. We are able to do paternity testing with or without samples from the mother, as well as maternity testing, grandparentage testing, sibling testing, and prenatal testing. Please contact us directly for further information.

Paternity Test (alleged father and fetus)

Prenatal parentage testing is a different type of parentage testing in which the father-child relationship can be identify before the child is born. The test allows the earliest possible confirmation of father-child relationship. This is particularly useful for cases where the genuine identity of the biological father must be known before childbirth.

Usually, methods of sample collection for prenatal parentage testing include Chorionic Villus Sampling or Amniocentesis. These methods are not only invasive, but cannot be conducted until at least 10 weeks into the pregnancy.
However, at Medtimes, we are able to perform the parentage test by using the blood of the mother (maternal blood). Currently, this is the only non-invasion prenatal paternity testing method, and can be performed after the 7th week of pregnancy.

Prenatal Autosomal Maternal Serum Paternity Test

Unlike Y-Chromosomal paternity testing, Autosomal Maternal Serum Paternity Test requires extremely advanced techniques for the separation and differentiation of fetal cf-DNAs. In normal circumstances, fetal cf-DNAs will be existing as low as 1% in the maternal plasma, and leading to the detection of fetal cf-DNAs difficult. In addition, due to the fact that the female baby's DNA signal will be significantly masked by maternal DNA, this makes the analyzing and extracting the fetal DNA further problematic.


Prenatal Non-invasive‧Gestational Week: 7 weeks

Usually, methods of sample collection for prenatal parentage testing include Chorionic Villus Sampling or Amniocentesis. These methods are not only invasive, but cannot be conducted until at least 10 weeks into the pregnancy. However, at Medtimes, we are able to perform the parentage test by using the blood of the mother (maternal blood). Currently, this is the only non-invasion prenatal paternity testing method, and can be performed after the 7th week of pregnancy.



Prenatal Test Details

Code Test Sample format TAT (Working day)
YPAT Y-chromosome Maternal Serum Paternity Test Maternal blood 10mL Cell-Free DNA BCT x 2
 7
1 alleged father
 Father, Buccal Swab x 2 or
3 mL EDTA Blood x 1 or
Hair sample (including follicles)
XYPAT Maternal Serum Paternity Test Maternal blood 10mL Cell-Free DNA BCT x 2 8-12
1 alleged father Buccal Swab x 2 or
3 mL EDTA Blood x 1 or
Hair sample (including follicles)


Postnatal Test Details

Code Test Sample format TAT (Working day)
1 alleged father/mother Buccal Swab x 3
PATL Paternity Test
(Legal Use)
 Child Buccal Swab x 3 or
3 mL EDTA Blood x 1 		14
1 alleged father/mother Buccal Swab x 3 or
3 mL EDTA Blood x 1
PATN Paternity
(Non-Legal Use)
 Child Buccal Swab x 3 or
3 mL EDTA Blood x 1 		7
1 alleged father/mother Buccal Swab x 3 or
3 mL EDTA Blood x 1


Note

1. Please do not eat or drink for at least 1 hour before the sampling.

2. If a blood transfusion was received in the past 3 months, or an allogeneic hematopoietic progenitor cell transplantation (bone marrow transplantation) was received at any time, false results can be obtained. For enquiries, please contact Customer Service at 3585 8533.





 Enquiries & Appointments: 3585 8533



What is relationship testing?

Relationship testing is done to determine various types of biological relationships.
For example, a grandparentage test can be conducted to determine if a biological relationship exists between the alleged grandparent and the child, in cases where the alleged father is not available to do the test. Other types of relationship tested include twins, sibling, aunt/uncle, cousin, and nephew/niece.

How is it done?

To carry out the test, all we need are genomic DNA from the two test subjects. Genomic DNA can be obtained from buccal swab and whole blood. We then compare the lengths of specific repeated DNA sequences in the chromosomes of the two test subjects. From there, we will be able to accurately determine the existence of a biological relationship between them.

Test method and theory

Short Tandem Repeat (STR) DNA typing is used to conduct the relationship testing. STRs are short repeated DNA sequences found in the chromosome of every individual. An individual inherits one copy of an STR from each parent, and unrelated people almost certainly have different repeat units. Thus, STR is an effective marker of biological relationships.

Code Test Sample Format TAT (Working day)
PATL Relationship Test
(Legal Use)
 Buccal Swab x 2 or 3ml EDTA Blood x 1 14
PATN Relationship Test
(Non-Legal Use) 		Buccal Swab x 2 or 3ml EDTA Blood x 1 7


Note

1. Please do not eat or drink for at least 1 hour before the sampling.

2. If a blood transfusion was received in the past 3 months, or an allogeneic hematopoietic progenitor cell transplantation (bone marrow transplantation) was received at any time, false results can be obtained. For enquiries, please contact Customer Service at 3585 8533.




 Enquiries & Appointments: 3585 8533



About Our Test

WHO-approved RT-PCR technique is chosen by Medtimes Medical Group to detect the ribonucleic acid (RNA) of the COVID-19 virus by amplifying specific deoxyribonucleic acid (RNA/DNA) fragments. COVID-19 PCR testing will be conducted by Medtimes Molecular Laboratory, which is a branch under Medtimes Medical Group and successfully obtains the accreditation of HOKLAS ISO 15189. Medtimes Molecular Laboratory is one of the local COVID-19 RT-PCR testing institutions recognized by HKSAR Government, the laboratory is able to issue recognized negative test certificate for both traveling and compulsory-testing purpose.The PCR testing also proves its efficacy and capabilities by passing SARS-CoV-2 proficiency test of Centre for Health Protection of HKSAR Government.

Travel Restriction

According to the COVID-19 pandemic, many countries have issued travel-restrictions, visa-services suspension and quarantine measures to foreign tourists. Travelers are required to show the negative result of COVID-19 Test. Different countries and governments have different requirements for the COVID-19 Test, such as designated specimen types. Since the restrictions may change anytime, the information is for reference only. Clients should follow the latest information released by the official government of certain countries.

Suitable for people who are over the age of 3, especially the following groups:

Medtimes is a Hong Kong SAR Government recognised testing institutions, Government-recognised reports are suitable for compulsory testing, travel to and from the Mainland and Macau.


    •      No walk-in reservation is available in Medtimes clinics. All clients are required to conduct CS after online booking.
         Please make appointment through online booking at least 1 working day in advance.
         Please arrive at the clinic on your appointment time(for sampling collection), otherwise the reporting release time may be affected due to late arrival.
         Once the online booking for the COVID-19 PCR test is confirmed, no rescheduling, cancellation or refund will be accepted.
         Please carefully read this Terms and Conditions before the test.

     Inquiry & Booking: 3585 8533



    FAQ

    Any important notice before the test?

    1. Please read thisT&C.
    2. PCR testing requirements may vary with regard to the different purpose (such as travel restrictions in countries or regions) in which the specimens were collected, please check the sample requirement and report validity period before the test.
    3. Preparation before go to collect specimens:
    - Present valid Hong Kong identity cards or other valid identity documents. If you are travelling to Mainland China, Macau or depart from HK, you also need to bring along the document required for entry to your destination. (e.g. Mainland Travel Permit for Hong Kong and Macau Residents, passport or other travel document).
    - Nasal and Throat Swabs specimens Collection:Please avoid using nasal spray within 10 hours before your appointment.

    How will I receive my PCR test report?

    Please go to https://www.medtimes.com.hk/report.html enter customer name and report number for check or download the test report. (The report release time may be delayed due to unforeseen circumstances. For example, the sample quality problem needs to be re-sampled and tested. Therefore, we recommend outbound travelers reserve sufficient time to complete the test and allow ample time before the flight departure. Medtimes will not have or accept any liability, obligation or responsibility whatsoever for any delay, including claims for damages due to inability to travel or work.)

    Why CT value will show on my PCR test report?

    When the test result is positive, the report will show the Ct value. Ct value is an indicator for nucleic acid detection to measure the concentration and infectivity of virus genes. When the concentration of viral genes is high, such as newly infected or severely ill patients, the Ct value will be low, and the viral infectivity will be higher; if the viral gene concentration is low, the Ct value will be high, and the infectivity will naturally be low. Medtimes PCR test will detect three different target genes of the virus to prevent errors in the test results, so there will have 3 Ct values on positive test reports (E Gene Ct, RdRP/S Gene Ct & ; N Gene Ct). Most institutions or related departments will use RdRP/S Gene or N Gene as the target gene. Positive Report Sample

    - More Questions -


    • Related Information






    Gynecology

    Code Test Sample format TAT (working day)
    CTDNA Chlamydia trachomatis DNA HVS/ LVS Swab x 1 1
    NGDNA Neisseria Gonorrhoeae DNA 1
    MGDNA Mycoplasma Genitalium DNA 1
    UUDNA Ureaplasma urealyticum DNA 1
    TVDNA Trichomonas vaginalis (TV) DNA 1
    CADNA Candida albicans (CA) DNA 1
    GVDNA Gardnerella vaginalis DNA 1
    SA B DNA Group B Strep. (S. agalactiae) DNA 1
    TOXDNA Toxoplasma gondii DNA 3mL EDTA Blood x 1 or Amniotic fluid 1
    HSVDNA Herpes Simplex Virus (HSV) 1&2 DNA Lesion Swab x 1 1
    MHDNA Mycoplasma Hominis DNA HVS/ LVS Swab x 1 1
    ZIKA ZIKA Virus RNA Test 6mL EDTA Blood x 1 2

    Pediatrics

    Code Test Sample format TAT (working day)
    CMVDNA CMVDNA 6mL EDTA Blood x 1 1
    RUBDNA Rubella Virus DNA Nasopharyngeal or throat Swab x 1 1
    VZVDNA Varicella - Zoster Virus DNA Lesion Swab x 1 1

    Hepatitis

    Code Test Sample format TAT (working day)
    HBVDNA Hepatitis B Virus DNA (Quantitative) 3mL EDTA Blood x 1 1
    HBVDNAQL Hepatitis B Virus DNA (Qualitative) 6mL EDTA Blood x 1 3
    HBVHSDNA HBV, DNA Hight Sensitivity Viral Load, Quantitative 3
    HBVMDR HBV Multi-drug Resistance Genotyping (LAM + TEL + ADE + ETV + TDF) 3
    HBVYMDD HBV Lamivudine Resistance Genotyping-YMDD 3
    HCVGENO HCV Genotyping 3
    HCVRNA HCV - RNA (Quantitative) 3
    HCVRNA-QL HCV - RNA (Qualitative) 3

    Epstein–Barr virus

    Code Test Sample format TAT （working day）
    EBVDNA EBV DNA (Quantitative) Nasopharyngeal Swab x 1 or
    6mL EDTA Blood x 1     		2
    EBVDNA-QL EBV DNA (Qualitative) 2

    HPV

    Code Test Sample format TAT （working day）
    HPV2 HPV Genotyping for 16, 18 Thinprep or
    Swab x 1 or
    Tissue     		1
    HPV4 HPV Genotyping for 6,11,16,18 1
    HPV13 HPV Genotyping Test (13 genotypes) 3
    HPV37 HPV Genotyping Test (37 genotypes) 3



     Enquiries & Appointments: 3585 8533



    Inherited MYH7 Cardiac SNPs Test

    Primary cardiomyopathy is an inherited heart muscle disease, which increases the contractility and cardiac output in filling and pumping blood into the heart, eventually leading to irreversible heart dysfunction. This disease affects all ages and races, also associates with heart failure, arrhythmia and sudden cardiac death. The common type hypertrophic cardiomyopathy is the enlargement of heart muscle without any noticeable pathological reason, and it is known as the main cause of sudden cardiac death in young athletes.

    Medtimes in-house developed MYH7 Cardiac Genetic Test targets MYH7 gene that relates to familial hypertrophic cardiomyopathy, primary dilated cardiomyopathy, myosin storage myopathy and so on. This test helps to identify carriers before the on-set of the disease, allows affected individual to recognize the potential risk and perform preventive actions according to the instructions of cardiologist.

    測試編碼 測試名稱 樣本要求 測試需時 （工作天）
    MYH7 Inherited MYH7 Cardiac SNPs Test Buccal Swab x 2 5
    $1200

    隱性基因疾病是甚麼？


    人體的染色體及基因分別遺傳自父母，孩子不但會遺傳到父母的身體及外貌特徵，包括眼睛、血型等；有些更會遺傳雙親的天賦才藝，在特定領域有傑出的成就。

    如果父母遺傳給下一代的並不是天賦外貌，竟然是不幸的隱性致病基因，為什麼從來不知道呢？

    很多時隱性遺傳病基因攜帶者是健康及無明顯症狀，也沒有家族遺傳病史，即使致病基因雖然會代代相傳，但並非每個家族都會出現患者。因此，大部份隱性遺傳病基因攜帶者都不知道自己帶有致病的突變基因。如果父母雙方都帶有的隱性致病基因，下一代就有機會是重症患者。

    研究顯示，平均每1個人就帶有2.8個帶有隱性致病基因。如果父母都有隱性致病基因，有3/4機會將相關基因遺傳給下一代，孩子有1/4機會是重症患者，嚴重更會終身畸形、殘障及死亡。

    隱性基因疾病檢測重要嗎？

    常見遺傳病如地中海貧血，患者或需終生輸血、死亡率高；嚴重遺傳病如多囊腎病，患者中年時期才發病且無藥可醫，只可靠洗腎延緩惡化；晚發型龐貝氏症初期症狀與其它神經肌肉疾病症狀相似，33%病患曾被誤診為其他疾病，導致延誤治療時機。因此，若能夠盡早知道下一代患上隱性遺傳病的風險，就可以幫助計劃生育的夫婦及於懷孕初期的孕婦預先作準備。

    基康檢隱性疾病基因檢測

    HeredScreen基康檢隱性遺傳病基因檢測可讓夫婦及早發現隱性致病基因，如發現二人均有相同的疾病基因，早期懷孕的孕婦可得知寶寶日後會否有健康及發育問題。夫婦可盡早於懷孕時、寶寶出生後、日後成長方面，規劃好所需的支援。

    ⦁　全面涵蓋300+種隱性基因疾病，覆蓋香港最常見的隱性遺傳病

    ⦁　採用次世代測序技術(NGS)超大規模測序，一次過檢查數以百萬計基因段，每個位置檢查最少50次

    ⦁　準確率高達 99.9%

    ⦁　有效分辨脊髓性肌肉萎縮症的沉默基因攜帶者

    ⦁　採用最新測序技術「固態測序」，將整條FMR1基因讀取，一次性檢測就能精確評估脆性X綜合症風險

    ⦁　詳細報告列明風險疾病資訊、基因狀況及疾病風險等

    測試適用對象

    適用對象
    進行婚前檢查伴侶 計劃懷孕夫婦 早期懷孕階段孕婦 進行人工受孕夫婦


    測試詳情

    測試代碼 測試名稱 樣本要求 測試需時 （工作天） 檢測費用
    HERED 420+隱性基因疾病檢測 6mL EDTA採血管 x 1 30
    $7,900




    $7900

    什麼是地中海貧血?

    地中海貧血，簡稱地貧，是一種遺傳性血液疾病。地貧患者的身體會產生異常大小或型狀的血紅蛋白/血色素/血紅素，以致無法提供足夠氧氣到身體所有細胞，異常導致大量紅血球破壞，造成貧血。 

    地中海貧血的類型

    血紅蛋白由甲型(α)蛋白鏈及乙型(β)蛋白鏈組成。
    每一個人會擁有兩組血紅蛋白基因；一組來自父親，另一組來自母親。

    地貧大致可分為甲型(α)和乙型(β)兩類，
    而按照嚴重程度再分為輕型及重型。

    輕型地中海貧血症主要遺傳了父親或母親的異常基因，
    一般都沒有特別明顯病徵。
    而重型地中海貧血症則遺傳了父母雙方的異常基因，會嚴重貧血。


    地中海貧血來自遺傳



    夫婦都沒有地貧基因
    下一代不可能有地貧基因





    夫婦任何一方帶有地貧基因
    子女遺傳地貧基因機會為50%而成為地貧基因攜帶者




    夫婦二人都帶有地貧基因
    子女有25%機會是健康的
    50%機會患上輕型地貧
    25%機會患上重型地貧


    地中海貧血基因檢測

    現時，甲型(α)和乙型(β)地貧基因可以靠驗血檢測出來。一般測試會進行血紅蛋白基因分析，檢測有否異常狀況。
    時代基因檢測中心研發的地貧測試可直接進行基因測試，驗出異常基因。

    測試代碼 測試名稱 樣本要求 測試需時 （工作天） 檢測費用
    HBADNA 地中海貧血基因檢測A 3mL EDTA採血管 x 1 或 口腔拭子 x 2 5 $3,200
    HBBDNA 地中海貧血基因檢測B 3mL EDTA採血管 x 1 或 口腔拭子 x 2 5 $3,200
    HBDNA 地中海貧血基因檢測A&B 3mL EDTA採血管 x 1 或 口腔拭子 x 2 5 $3,800

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    立即測試骨質疏鬆風險

    完成測試後，有機會獲免費骨質密度檢查 (DEXA) 乙次 或 骨質密度檢查優惠券乙張

    閣下資料將會用作此推廣活動聯絡用途，如因資料有誤而未能聯絡閣下，本公司一概不負上任何責任。

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